3-Acetoxymethyl-1-(4-methoxy-benzenesulfonyl)-azepane-2-carboxylic acid → 3-Benzofuran-2-yl-1-(4-methoxy-benzenesulfonyl)-2,3,4,7-tetrahydro-1H-azepine-2-carboxylic acid
Reaction equation
C([O:5][C:6]([C:8]1([C:26]2[O:30][C:29]3[CH:31]=[CH:32][CH:33]=[CH:34][C:28]=3[CH:27]=2)[CH2:14][CH2:13][CH:12]=[CH:11][CH2:10][N:9]1[S:15]([C:18]1[CH:23]=[CH:22][C:21]([O:24][CH3:25])=[CH:20][CH:19]=1)(=[O:17])=[O:16])=[O:7])(C)(C)C.C(OCC1CCCCN(S(C2C=CC(OC)=CC=2)(=O)=O)C1C(O)=O)(=O)C>>[O:30]1[C:29]2[CH:31]=[CH:32][CH:33]=[CH:34][C:28]=2[CH:27]=[C:26]1[C:8]1([C:6]([OH:7])=[O:5])[CH2:14][CH2:13][CH:12]=[CH:11][CH2:10][N:9]1[S:15]([C:18]1[CH:19]=[CH:20][C:21]([O:24][CH3:25])=[CH:22][CH:23]=1)(=[O:16])=[O:17]Participants
3
Reactant 2
Product 1
Procedure
3-Benzofuran-2-yl-1-(4-methoxy-benzenesulfonyl)-2,3,4,7-tetrahydro-1H-azepine-2-carboxylic acid was synthesized from 3-Benzofuran-2-yl-1-(4-methoxy-benzenesulfonyl)-2,3,4,7-tetrahydro-1H-azepine-2-carboxylic acid tert-butyl ester in the same manner as the procedures used for the preparation of 3-Acetoxymethyl-1-(4-methoxy-benzenesulfonyl)-azepane-2-carboxylic acid: MS (M-H)30 426.
Sources & evidence
- ORD record
- ord-0e37916ca168463d98f8eff0d380bc63
- Source dataset
- uspto-grants-2000_08
- Patent number
- US06107291
Reaction notes
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