Dimethylformamide → 4-Chloro-2-(trifluoromethyl)benzonitrile

Temperature

140 °C

100 g of 2-trifluoromethyl-4-chloro iodobenzene, 200 ml of dimethylformamide and 58.7 g of copper cyanide are introduced at 20° C., the reaction medium is heated for 3 hours at 140° C., left to cool down to 20° C., then poured into 600 ml of ice-cooled demineralized water. After filtering, rinsing with 3×200 ml of isopropyl ether, the aqueous phase is decanted and reextracted with 3×200 ml of isopropyl ether. The organic phases are combined and washed with 200 ml of demineralized water and dried. In this way 66.64 g of expected product is obtained.

1. waitleft
2. temperatureto cool down to 20° C.
3. filtrationAfter filtering
4. washrinsing with 3×200 ml of isopropyl ether
5. customthe aqueous phase is decanted
6. washwashed with 200 ml of demineralized water
7. customdried

ORD record

ord-c5d47cf897b949ceb9c93fd8f5f3314e

Source dataset

uspto-grants-2000_08

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US06107488