反应详情

温度

10 °C

Diethyl-4-(3-azidopropoxy)-2,6-pyridinedicarboxylate, prepared above, (11.0 g, 34 mmol) was treated with a solution of sodium hydroxide (4.0 g, 0.10 mol) in water (120 mL) at 90-100° C. for 40 min. The reaction mixture was cooled to 10° C. and acidified to pH 1-2 with concentrated hydrochloric acid. The mixture was heated to dissolve the resulting white precipitate. Upon cooling 6.8 g (75 %) of the title compound was obtained as white crystals.

1. temperatureThe mixture was heated
2. dissolutionto dissolve the resulting white precipitate