反应详情

温度

70 °C

To a mixture of dimethylmalonate (4 ml), 2-hydroxy-4-octyloxybenzaldehyde (2.50 g) and piperidine (0.1 ml) in methanol (10 ml) was added acetic acid (0.01 ml), and the mixture was stirred for 3 hours at 70° C. The solvents were removed under reduced pressure, and the residue was dissolved in ethyl acetate, and washed with 0.5N hydrochloric acid, water and brine, and dried over magnesium sulfate. The magnesium sulfate was filtered off, and filtrate was evaporated under reduced pressure, and the precipitate was collected by filtration, and washed with n-hexane, and dried to give Methyl 7-octyloxycoumarin-3-carboxylate (0.94 g).

1. customThe solvents were removed under reduced pressure
2. dissolutionthe residue was dissolved in ethyl acetate
3. washwashed with 0.5N hydrochloric acid, water and brine
4. dry with materialdried over magnesium sulfate
5. filtrationThe magnesium sulfate was filtered off
6. customfiltrate was evaporated under reduced pressure
7. filtrationthe precipitate was collected by filtration
8. washwashed with n-hexane
9. customdried