反应详情

The solution of 1-(4-Methoxycarbonylphenyl)-3-(4-pentyloxyphenyl)propane-1,3-dione (1.00 g) and hydroxylamine hydrochloride (567 mg) in methanol (10 ml) was refluxed for 10 hours. The reaction mixture was diluted with ethyl acetate (50 ml) and washed with water (50 ml×2), brine (50 ml). The organic layer was dried over magnesium sulfate and the solvents were removed under reduced pressure. The residue was triturated with acetonitrile (10 ml), collected by filtration, and dried under reduced pressure to give Methyl 4-[5-(4-pentyloxyphenyl)isoxazol-3-yl]benzoate (0.74 g).

1. washwashed with water (50 ml×2), brine (50 ml)
2. dry with materialThe organic layer was dried over magnesium sulfate
3. customthe solvents were removed under reduced pressure
4. customThe residue was triturated with acetonitrile (10 ml)
5. filtrationcollected by filtration
6. customdried under reduced pressure