反应详情

A suspension of 1-(4-n-Hexyloxybenzoyl)-2-(4-methoxycarbonylbenzoyl)hydrazine (1.00 g) in phosphorus oxychloride (5 ml) was refluxed for 1 hour. After cooling, the solution was concentrated under reduced pressure. The residue was poured into ice-water and extracted with dichloromethane. The organic layer was washed with water, brine and dried over magnesium sulfate. The solvents were removed under reduced pressure. The residue was triturated with acetonitrile, collected by filtration and dried under reduced pressure to give Methyl 4-[5-(4-n-hexyloxyphenyl)-1,3,4-oxadiazole-2-yl]benzoate (761 mg).

1. temperaturewas refluxed for 1 hour
2. temperatureAfter cooling
3. concentrationthe solution was concentrated under reduced pressure
4. additionThe residue was poured into ice-water
5. extractionextracted with dichloromethane
6. washThe organic layer was washed with water, brine
7. dry with materialdried over magnesium sulfate
8. customThe solvents were removed under reduced pressure
9. customThe residue was triturated with acetonitrile
10. filtrationcollected by filtration
11. customdried under reduced pressure