反应详情

温度

40 °C

To a solution of 4-bromobenzaldehyde oxime chloride (647 mg) and 4-n-pentyloxy-phenylacetylene (650 mg) in tetrahydrofuran (7 ml) was added triethylamine (0.5 ml) in tetrahydrofuran (5 ml) dropwise at 40° C. The solution was stirred at 40° C. for 30 minutes, poured into water and extracted with ethyl acetate. The organic layer was washed with H2O, brine and dried over magnesium sulfate. The solvents were removed under reduced pressure and the residue was triturated with acetonitrile. The precipitate was collected by filtration and dried to give 4-[5-(4-n-pentyloxyphenyl)isoxazol-3-yl]bromobenzene (0.59 g).

1. extractionextracted with ethyl acetate
2. washThe organic layer was washed with H2O, brine
3. dry with materialdried over magnesium sulfate
4. customThe solvents were removed under reduced pressure
5. customthe residue was triturated with acetonitrile
6. filtrationThe precipitate was collected by filtration
7. customdried