反应详情

A mixture of 5-bromo-5-phenylbarbituric acid (2.45 g), 4-(hydroxyethylidene)piperidine (1.053 g) and triethylamine (1.15 ml) in 50 ml of ethanol is refluxed for 2 hours. The solvent is evaporated under reduced pressure and the residue is purified by silica gel chromatography (40 g; eluent: ethyl acetate/petroleum ether 8:2), to give 450 mg of the product.

1. temperatureis refluxed for 2 hours
2. customThe solvent is evaporated under reduced pressure
3. customthe residue is purified by silica gel chromatography (40 g; eluent: ethyl acetate/petroleum ether 8:2)