Hydrochloric Acid → MLS002695130

HRID 1872561Notes

Reaction equation

HRID 1872561 reaction equation
[CH:1](=[C:8]1[C:13](=[O:14])[NH:12][C:11](=[O:15])[NH:10][C:9]1=[O:16])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[BH4-].[Na+].O.Cl>CO>[CH2:1]([CH:8]1[C:9](=[O:16])[NH:10][C:11](=[O:15])[NH:12][C:13]1=[O:14])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

6

Reactant 4

HCID 313Hydrochloric AcidHCID 962WaterHCID 2411295-Benzylidenebarbituric acidHCID 4311764Sodium borohydride

Product 1

HCID 260790MLS002695130

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To a suspension of 5-benzylidenebarbituric acid (4 g) in 200 ml of methanol are added portionwise 1.4 g of sodium borohydride. After 10 minutes from the end of the addition, 100 ml of water are added and the mixture is acidified with 1 N hydrochloric acid to pH=2. The solvent is evaporated off and the aqueous phase is extracted with ethyl acetate. The pooled extracts are dried over sodium sulfate and concentrated to dryness. 3.6 g of the product crystallize, m.p. 207-209° C.

Workup

  1. additionare added
  2. customThe solvent is evaporated off
  3. extractionthe aqueous phase is extracted with ethyl acetate
  4. dry with materialThe pooled extracts are dried over sodium sulfate
  5. concentrationconcentrated to dryness
  6. custom3.6 g of the product crystallize

Sources & evidence

ORD record
ord-71d22f8623274f3fb9e79433d3babf07
Source dataset
uspto-grants-2000_08
Patent number
US06110924

Reaction notes

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