Hydrogen Bromide → 5-Bromo-5-octylbarbituric acid

Participants

Reaction Conditions

Reaction Steps

To a suspension of 5-octylbarbituric acid (20 g) in 120 ml of water, cooled at 0-5° C., are added 12 ml of 48% hydrobromic acid and successively are dropped 4.72 ml of brornine. After 2 hours under stirring, the white solid which separated is recovered by filtration, washed with water and partitioned between 200 ml of diethyl ether and 100 ml of water.

Provenance & Evidence