Hydrogen Bromide → 5-Bromo-5-octylbarbituric acid

HRID 1872574Notes

Reaction equation

HRID 1872574 reaction equation
[CH2:1]([CH:9]1[C:14](=[O:15])[NH:13][C:12](=[O:16])[NH:11][C:10]1=[O:17])[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH3:8].[BrH:18]>O>[Br:18][C:9]1([CH2:1][CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH3:8])[C:14](=[O:15])[NH:13][C:12](=[O:16])[NH:11][C:10]1=[O:17]

Participants

4

Reactant 2

HCID 260Hydrogen BromideHCID 260794Octyl barbituric acid

Product 1

HCID 184088325-Bromo-5-octylbarbituric acid

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Conditions

Temperature
2.5 °C

Procedure

To a suspension of 5-octylbarbituric acid (20 g) in 120 ml of water, cooled at 0-5° C., are added 12 ml of 48% hydrobromic acid and successively are dropped 4.72 ml of brornine. After 2 hours under stirring, the white solid which separated is recovered by filtration, washed with water and partitioned between 200 ml of diethyl ether and 100 ml of water.

Workup

  1. customthe white solid which separated
  2. filtrationis recovered by filtration
  3. washwashed with water
  4. custompartitioned between 200 ml of diethyl ether and 100 ml of water

Sources & evidence

ORD record
ord-c7be68df5b024a02adaacf576eaed03d
Source dataset
uspto-grants-2000_08
Patent number
US06110924

Reaction notes

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