Sodium → HCID 15541137, compound

HRID 1872663Notes

Reaction equation

HRID 1872663 reaction equation
C([O:4][C:5]1[C:10]([CH3:11])=[CH:9][C:8]([O:12][CH2:13][C:14]([F:17])([F:16])[F:15])=[CH:7][C:6]=1[CH3:18])(=O)C.[Na]>CO>[CH3:11][C:10]1[CH:9]=[C:8]([O:12][CH2:13][C:14]([F:15])([F:16])[F:17])[CH:7]=[C:6]([CH3:18])[C:5]=1[OH:4]

Participants

4

Reactant 2

HCID 5360545SodiumHCID 15541136HCID 15541136, compound

Product 1

HCID 15541137HCID 15541137, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

The 2,6-dimethyl-4-(2,2,2-trifluoroethoxy)phenyl acetate (733 mg, 2.80 mmol) in methanol (10 mL) was treated with sodium metal and stirred at room temperature overnight. The solvent was removed and the residue partitioned between ethyl acetate and water. The organic layer was washed twice with brine and dried. The solvent was removed to give 2,6-dimethyl-4-(2,2,2-trifluoroethoxy)phenol.

Workup

  1. customThe solvent was removed
  2. customthe residue partitioned between ethyl acetate and water
  3. washThe organic layer was washed twice with brine
  4. customdried
  5. customThe solvent was removed

Sources & evidence

ORD record
ord-251912e6f98a46a8b2073cf868dd4646
Source dataset
uspto-grants-2000_08
Patent number
US06110937

Reaction notes

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