Hydrochloric Acid → HCID 69343836, compound

HRID 1872673Notes

Reaction equation

HRID 1872673 reaction equation
[Br:1][C:2]1[CH:16]=[C:15]([CH3:17])[C:5]([O:6][CH2:7][C@H:8]2[CH2:13][CH2:12][CH2:11][N:10]([CH3:14])[CH2:9]2)=[C:4]([CH3:18])[CH:3]=1.[ClH:19]>CCOCC>[ClH:19].[Br:1][C:2]1[CH:16]=[C:15]([CH3:17])[C:5]([O:6][CH2:7][C@H:8]2[CH2:13][CH2:12][CH2:11][N:10]([CH3:14])[CH2:9]2)=[C:4]([CH3:18])[CH:3]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 9818218HCID 9818218, compound

Product 1

HCID 69343836HCID 69343836, compoundYield 87%

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent2×

Procedure

The (S)-3-(4-bromo-2,6-dimethylphenoxymethyl)-1-methylpiperidine was dissolved in ether (600 mL) and treated with a 1M solution of hydrochloric acid in ether (90 mL). The resulting white precipitate was filtered and dried in vacuo to give (S)-3-(4-bromo-2,6-dimethylphenoxymethyl)-1-methylpiperidine hydrochloride (25.5 g, 87%), m.p. 209.7-210.5° C.

Workup

  1. filtrationThe resulting white precipitate was filtered
  2. customdried in vacuo

Sources & evidence

ORD record
ord-a7139a5417204e02b44715a2a4dcc665
Source dataset
uspto-grants-2000_08
Patent number
US06110937

Reaction notes

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