Hydrochloric Acid → HCID 70238480, compound

HRID 1872677Notes

Reaction equation

HRID 1872677 reaction equation
[CH:1]1([CH2:4][N:5]2[CH2:10][CH2:9][CH2:8][C@H:7]([CH2:11][O:12][C:13]3[C:18]([CH3:19])=[CH:17][CH:16]=[CH:15][C:14]=3[CH3:20])[CH2:6]2)[CH2:3][CH2:2]1.[ClH:21]>CCOCC>[ClH:21].[CH:1]1([CH2:4][N:5]2[CH2:10][CH2:9][CH2:8][C@H:7]([CH2:11][O:12][C:13]3[C:14]([CH3:20])=[CH:15][CH:16]=[CH:17][C:18]=3[CH3:19])[CH2:6]2)[CH2:3][CH2:2]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 54284623HCID 54284623, compound

Product 1

HCID 70238480HCID 70238480, compoundYield 66%

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent2×

Procedure

The (S)-1-cyclopropylmethyl-3-(2,6-dimethylphenoxymethyl)piperidine was dissolved in dry ether (125 mL) and treated with 1M hydrochloric acid in ether (18.9 mL). The white precipitate was collected and dried under vacuum to give (S)-1-cyclopropylmethyl-3-(2,6-dimethylphenoxymethyl)-piperidine hydrochloride, (3.6 g, 66%), m.p. 137.3-137.5° C.

Workup

  1. customThe white precipitate was collected
  2. customdried under vacuum

Sources & evidence

ORD record
ord-59ef2a61ea444ce397247bad89838c85
Source dataset
uspto-grants-2000_08
Patent number
US06110937

Reaction notes

Loading…