反应详情

A solution of 5-chloro-2,4-dimethoxybenzoic acid (6.4 g) in dichloromethane (250 ml) was treated with thionyl chloride (30 ml) and the mixture heated at reflux for 18h. Removal of volatile material in vacuo afforded the title compound as a white solid (6.6 g).

1. temperaturethe mixture heated
2. temperatureat reflux for 18h
3. customRemoval of volatile material in vacuo