1-Iodopropane → 1,2,3,4-Tetrahydro-2-propyl-5-isoquinolinamine

HRID 1872696Notes

Reaction equation

HRID 1872696 reaction equation
[NH2:1][C:2]1[CH:11]=[CH:10][CH:9]=[C:8]2[C:3]=1[CH:4]=[CH:5][N:6]=[CH:7]2.I[CH2:13][CH2:14][CH3:15].[BH4-].[Na+]>>[NH2:1][C:2]1[CH:11]=[CH:10][CH:9]=[C:8]2[C:3]=1[CH2:4][CH2:5][N:6]([CH2:13][CH2:14][CH3:15])[CH2:7]2

Participants

4

Reactant 3

HCID 336431-IodopropaneHCID 707665-AminoisoquinolineHCID 4311764Sodium borohydride

Product 1

HCID 186874211,2,3,4-Tetrahydro-2-propyl-5-isoquinolinamine

Procedure

The title compound was prepared by treatment of 5-aminoisoquinoline with iodopropane followed by reduction with sodium borohydride using procedures analogous to those described in Preparation 1 and Preparation 2.

Workup

  1. customthose described in Preparation 1 and Preparation 2

Sources & evidence

ORD record
ord-e9aacd2c7ed448b5a8ad2b9095754706
Source dataset
uspto-grants-2000_08
Patent number
US06110934

Reaction notes

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