反应详情

To a solution of 2-methoxy-4-iso-propyl benzoic acid (prepared in an analogous manner to Preparation 37, 4-tert-butyl-2-methoxy benzoic acid) (7.0 g, 36.0 mmol) in chloroform (100 ml) was added bromine (1.86 ml) in chloroform (20 ml) dropwise. The reaction was stirred at room temperature overnight. Evaporation in vacuo afforded an oil (9.27 g). m /z (CI): 275, 273 (MH+ ; 70%).

1. customEvaporation in vacuo