Bromine → HCID 22597763, compound

HRID 1872706Notes

Reaction equation

HRID 1872706 reaction equation
[CH3:1][O:2][C:3]1[CH:11]=[C:10]([CH:12]([CH3:14])[CH3:13])[CH:9]=[CH:8][C:4]=1[C:5]([OH:7])=[O:6].C(C1C=CC(C(O)=O)=C(OC)C=1)(C)(C)C.[Br:30]Br>C(Cl)(Cl)Cl>[Br:30][C:9]1[C:10]([CH:12]([CH3:14])[CH3:13])=[CH:11][C:3]([O:2][CH3:1])=[C:4]([CH:8]=1)[C:5]([OH:7])=[O:6]

Participants

5

Reactant 3

HCID 24408BromineHCID 126137372-Methoxy-4-(propan-2-yl)benzoic acidHCID 126137394-tert-Butyl-2-methoxybenzoic acid

Product 1

HCID 22597763HCID 22597763, compound

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent2×

Procedure

To a solution of 2-methoxy-4-iso-propyl benzoic acid (prepared in an analogous manner to Preparation 37, 4-tert-butyl-2-methoxy benzoic acid) (7.0 g, 36.0 mmol) in chloroform (100 ml) was added bromine (1.86 ml) in chloroform (20 ml) dropwise. The reaction was stirred at room temperature overnight. Evaporation in vacuo afforded an oil (9.27 g). m /z (CI): 275, 273 (MH+ ; 70%).

Workup

  1. customEvaporation in vacuo

Sources & evidence

ORD record
ord-19894fa651b54de497338116275ac609
Source dataset
uspto-grants-2000_08
Patent number
US06110934

Reaction notes

Loading…