2,4-Dimethoxybenzoyl chloride → HCID 18687443, compound

HRID 1872710Notes

Reaction equation

HRID 1872710 reaction equation
[NH2:1][C:2]1[CH:11]=[CH:10][CH:9]=[C:8]2[C:3]=1[CH2:4][CH2:5][N:6]([CH3:12])[CH2:7]2.[CH3:13][O:14][C:15]1[CH:23]=[C:22]([O:24][CH3:25])[CH:21]=[CH:20][C:16]=1[C:17]([Cl:19])=[O:18]>>[ClH:19].[CH3:12][N:6]1[CH2:5][CH2:4][C:3]2[C:8](=[CH:9][CH:10]=[CH:11][C:2]=2[NH:1][C:17](=[O:18])[C:16]2[CH:20]=[CH:21][C:22]([O:24][CH3:25])=[CH:23][C:15]=2[O:14][CH3:13])[CH2:7]1

Participants

3

Reactant 2

HCID 27347192,4-Dimethoxybenzoyl chlorideHCID 141712692-Methyl-1,2,3,4-tetrahydroisoquinolin-5-amine

Product 1

HCID 18687443HCID 18687443, compound

Procedure

To a solution of 5-amino-2-methyl-1,2,3,4-tetrahydroisoquinoline (0.25 g, 1.54 mmol) in ethyl acethate (5 ml) was added 2,4-dimethoxybenzoyl chloride (0.263 g 1.54 mmol). The mixture was stirred under argon for 2 h before the precipithate was filtered off and dried to afford the title compound as white solid.

Workup

  1. filtrationwas filtered off
  2. customdried

Sources & evidence

ORD record
ord-c0251fcf0e494f32bc10afc48f0801c0
Source dataset
uspto-grants-2000_08
Patent number
US06110934

Reaction notes

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