5-Chloro-2-methoxy-4-nitrobenzoic acid → N-(2-Methyl-1,2,3,4-tetrahydroisoquinolin-5-yl)-5-chloro-2-methoxy-4-nitrobenzamide

HRID 1872719Notes

Reaction equation

HRID 1872719 reaction equation
[NH2:1][C:2]1[CH:11]=[CH:10][CH:9]=[C:8]2[C:3]=1[CH2:4][CH2:5][N:6]([CH3:12])[CH2:7]2.[Cl:13][C:14]1[C:15]([N+:25]([O-:27])=[O:26])=[CH:16][C:17]([O:23][CH3:24])=[C:18]([CH:22]=1)[C:19](O)=[O:20]>>[CH3:12][N:6]1[CH2:5][CH2:4][C:3]2[C:8](=[CH:9][CH:10]=[CH:11][C:2]=2[NH:1][C:19](=[O:20])[C:18]2[CH:22]=[C:14]([Cl:13])[C:15]([N+:25]([O-:27])=[O:26])=[CH:16][C:17]=2[O:23][CH3:24])[CH2:7]1

Participants

3

Reactant 2

HCID 137856695-Chloro-2-methoxy-4-nitrobenzoic acidHCID 141712692-Methyl-1,2,3,4-tetrahydroisoquinolin-5-amine

Product 1

HCID 18687433N-(2-Methyl-1,2,3,4-tetrahydroisoquinolin-5-yl)-5-chloro-2-methoxy-4-nitrobenzamide

Procedure

The title compound was prepared in an analogous manner to Example 1 from 5-amino-2-methyl-1,2,3,4-tetrahydroisoquinoline and 5-chloro-2-methoxy-4-nitrobenzoic acid.

Sources & evidence

ORD record
ord-4d41b0099f2f466eabf0cd8106ae4943
Source dataset
uspto-grants-2000_08
Patent number
US06110934

Reaction notes

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