HuagongsheHuagongshe Chemistry Print Report · For research reference only
2,2,2-trifluoro-N-(2-hydroxyphenyl)acetamide → 2-Amino-3-ethyl-4-trifluoroacetamidophenol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2,2,2-trifluoro-N-(2-hydroxyphenyl)acetamide | HCID 13278497 | — |
| Reactant | 3-Ethyl-2-nitro-4-trifluoroacetamidophenol | HCID 15480139 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 2-Amino-3-ethyl-4-trifluoroacetamidophenol | HCID 15480140 | — |
Reaction Steps
To a solution of 3-ethyl-2-nitro-4-trifluoroacetamidophenol (18.21 mmol) and 10% palladium-on-carbon (0.45 g) in methanol (100 mL) is shaken under an atmosphere of hydrogen (50 psi) for three hours. The mixture is filtered through Celite and concentrated under reduced pressure to yield 2-amino-3-ethyl. trifluoroacetamidophenol.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06110952 |
| Source dataset | uspto-grants-2000_08 |
| ORD ID | ord-d7c047e01c214b298957aa88ecb837bd |
| Source note | uspto-grants-2000_08 |