反应详情

To a solution of 3-hydroxydodecanoic acid (0.26 g) in tetrahydrofuran (4 ml) was added 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride (0.18 g) and 1-hydroxybenzotriazole (0.24 g). After stirring for 30 minutes, 28% ammonium hydroxide (0.17 ml) was added and the mixture was stirred at room temperature overnight. Then, the mixture was diluted with ethyl acetate (100 ml) and washed with 0.1 N-hydrochloric acid (100 ml×2), saturated sodium bicarbonate (50 ml), and brine (50 ml). After drying over magnesium sulfate and evaporation, the residue was recrystallized from isopropyl alcohol (1 ml) to give 3-hydroxydodecanamide (0.20 g).

1. stirringthe mixture was stirred at room temperature overnight
2. washwashed with 0.1 N-hydrochloric acid (100 ml×2), saturated sodium bicarbonate (50 ml), and brine (50 ml)
3. dry with materialAfter drying over magnesium sulfate and evaporation
4. customthe residue was recrystallized from isopropyl alcohol (1 ml)