反应详情

To an ice-cooled solution of tridecanal (1.0 g), methyl 3-aminopropionate hydrochloride (704 mg), and sodium acetate (414 mg) in methanol (20 ml) was added sodium cyanoborohydride (317 mg). After stirring for 45 minutes, the mixture was quenched with water (20 ml), concentrated, and extracted with ethyl acetate (40 ml). The organic phase was washed with brine, dried, and concentrated under reduced pressure. The residue was purified on silica gel, eluting with 5% methanol in chloroform to give methyl 3-tridecylaminopropionate (0.78 g).

1. customthe mixture was quenched with water (20 ml)
2. concentrationconcentrated
3. extractionextracted with ethyl acetate (40 ml)
4. washThe organic phase was washed with brine
5. customdried
6. concentrationconcentrated under reduced pressure
7. customThe residue was purified on silica gel
8. washeluting with 5% methanol in chloroform