3-(1,4-Dioxa-spiro[4,5]dec-8-yl)-5-fluoro-1H-indole → 3-(1,4-Dioxa-spiro[4,5]dec-8-yl)-6-fluoro-1H-indole

HRID 1872831Notes

Reaction equation

HRID 1872831 reaction equation
[CH2:1]1[O:20][C:4]2([CH2:9][CH2:8][CH:7]([C:10]3[C:18]4[C:13](=[CH:14][CH:15]=[C:16](F)[CH:17]=4)[NH:12][CH:11]=3)[CH2:6][CH2:5]2)[O:3][CH2:2]1.[F:21]C1C=C2C(C(C3CCCCC=3)=CN2)=CC=1>>[CH2:1]1[O:20][C:4]2([CH2:9][CH2:8][CH:7]([C:10]3[C:18]4[C:13](=[CH:14][C:15]([F:21])=[CH:16][CH:17]=4)[NH:12][CH:11]=3)[CH2:6][CH2:5]2)[O:3][CH2:2]1

Participants

3

Reactant 2

HCID 105643253-(1,4-Dioxa-spiro[4,5]dec-8-yl)-5-fluoro-1H-indoleHCID 70106291HCID 70106291, compound

Product 1

HCID 184140863-(1,4-Dioxa-spiro[4,5]dec-8-yl)-6-fluoro-1H-indoleYield 60%

Procedure

This compound was prepared in the manner as described above for (2a) by replacing 4-(5-fluoro-1H-3-indolyl)-cyclohex-3-en-ethylene ketal with 4-(6-fluoro-1H-3-indolyl)-cyclohex-3-en-isomer ethylene ketal (9.54 g) in 60% yield (5.83 g) as a white solid: mp 158-159° C.

Workup

  1. customThis compound was prepared in the manner

Sources & evidence

ORD record
ord-4100da85ac334592a847887dcf4a7a11
Source dataset
uspto-grants-2000_08
Patent number
US06110956

Reaction notes

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