HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-(1,4-Dioxa-spiro[4,5]dec-8-yl)-5-fluoro-1H-indole → 3-(1,4-Dioxa-spiro[4,5]dec-8-yl)-6-fluoro-1H-indole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-(1,4-Dioxa-spiro[4,5]dec-8-yl)-5-fluoro-1H-indole | HCID 10564325 | — |
| Reactant | HCID 70106291 | HCID 70106291 | — |
| Product | 3-(1,4-Dioxa-spiro[4,5]dec-8-yl)-6-fluoro-1H-indole | HCID 18414086 | 60% |
Reaction Steps
This compound was prepared in the manner as described above for (2a) by replacing 4-(5-fluoro-1H-3-indolyl)-cyclohex-3-en-ethylene ketal with 4-(6-fluoro-1H-3-indolyl)-cyclohex-3-en-isomer ethylene ketal (9.54 g) in 60% yield (5.83 g) as a white solid: mp 158-159° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06110956 |
| Source dataset | uspto-grants-2000_08 |
| ORD ID | ord-4100da85ac334592a847887dcf4a7a11 |
| Source note | uspto-grants-2000_08 |