4-(5-Fluoro-1H-indol-3-YL)cyclohexanone → 4-(6-Fluoro-1H-indol-3-YL)cyclohexanone

HRID 1872832Notes

Reaction equation

HRID 1872832 reaction equation
FC1C=C2C(=CC=1)NC=C2C1CCC(=O)CC1.C1O[C:21]2([CH2:26][CH2:25][CH:24]([C:27]3[C:35]4[C:30](=[CH:31][C:32]([F:36])=[CH:33][CH:34]=4)[NH:29][CH:28]=3)[CH2:23][CH2:22]2)[O:20]C1>>[F:36][C:32]1[CH:31]=[C:30]2[C:35]([C:27]([CH:24]3[CH2:23][CH2:22][C:21](=[O:20])[CH2:26][CH2:25]3)=[CH:28][NH:29]2)=[CH:34][CH:33]=1

Participants

3

Reactant 2

HCID 107046834-(5-Fluoro-1H-indol-3-YL)cyclohexanoneHCID 184140863-(1,4-Dioxa-spiro[4,5]dec-8-yl)-6-fluoro-1H-indole

Product 1

HCID 154812814-(6-Fluoro-1H-indol-3-YL)cyclohexanone

Procedure

This compound was prepared in the manner as described above for (3a) by replacing 4-(5-fluoro-1H-3-indolyl)-cyclohexanone ethylene ketal with 4-(6-fluoro-1H-3-indolyl)-cyclohexanone ethylene ketal (5.4 g) in 99% (19.3 g) yield as a white solid: mp 102-105° C.

Workup

  1. customThis compound was prepared in the manner
  2. customyield as a white solid

Sources & evidence

ORD record
ord-5c78478023674d2397a473ce0806585d
Source dataset
uspto-grants-2000_08
Patent number
US06110956

Reaction notes

Loading…