참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Benzene | HCID 241 | — |
| 반응물 | Chloride | HCID 312 | — |
| 반응물 | Ethyl Acetate | HCID 8857 | — |
| 반응물 | Tin tetrachloride | HCID 24287 | — |
| 반응물 | 8-Tert-butyl-4,4-dimethylthiochromane | HCID 10799730 | — |
| 용매 | Diethyl Ether | HCID 3283 | — |
| 생성물 | 8-tert-Butyl-4,4-dimethyl-6-(1-oxopentyl)-thiochromane | HCID 10615540 | 37% |
반응 단계
To 500 mg (2.1 mmol) of 8-tert-butyl-4,4-dimethylthiochromane and 0.29 mL (2.34 mmol) of pentlanoyl chloride in 10 mL benzene at 0° C. is added 0.27 mL (2.34 mmol) of tin tetrachloride. The reaction is allowed to stir 1 hour at 0° C. and is then diluted with ether and washed with water and 10% sodium chloride. The product is purified by flash silica gel chromatography, eluting with 7:3 hexane:ethyl acetate to give 250 mg (37% yield) of the title compound.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US06110960 |
|---|
| 출처 데이터셋 | uspto-grants-2000_08 |
|---|
| ORD ID | ord-03e2d76974674705834957145ca0c799 |
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| 출처 메모 | uspto-grants-2000_08 |
|---|
