反应详情

温度

0 °C

To 500 mg (2.1 mmol) of 8-tert-butyl-4,4-dimethylthiochromane and 0.29 mL (2.34 mmol) of pentlanoyl chloride in 10 mL benzene at 0° C. is added 0.27 mL (2.34 mmol) of tin tetrachloride. The reaction is allowed to stir 1 hour at 0° C. and is then diluted with ether and washed with water and 10% sodium chloride. The product is purified by flash silica gel chromatography, eluting with 7:3 hexane:ethyl acetate to give 250 mg (37% yield) of the title compound.

1. washwashed with water and 10% sodium chloride
2. customThe product is purified by flash silica gel chromatography
3. washeluting with 7:3 hexane