Hydrochloric Acid → 1956306-41-4

HRID 1872885Notes

Reaction equation

HRID 1872885 reaction equation
[CH2:1]([O:3][C:4]([C:6]1([N:14]=C(C2C=CC=CC=2)C2C=CC=CC=2)[CH2:12][CH:11]2[O:13][CH:8]([CH2:9][CH2:10]2)[CH2:7]1)=[O:5])[CH3:2].[ClH:28]>C(OCC)C>[ClH:28].[CH2:1]([O:3][C:4]([C:6]1([NH2:14])[CH2:12][CH:11]2[O:13][CH:8]([CH2:9][CH2:10]2)[CH2:7]1)=[O:5])[CH3:2]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 544280513-(Benzhydrylideneamino)-8-oxabicyclo[3.2.1]octane-3-carboxylic Acid Ethyl Ester

Product 1

HCID 699571681956306-41-4

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

A two-phase mixture of 3-(benzhydrylideneamino)-8-oxabicyclo[3.2.1]octane-3-carboxylic acid ethyl ester (1.4 grams, 3.9 mmol) in aqueous 1N hydrochloric acid solution (100 mL) and diethyl ether (100 mL) was stirred at room temperature overnight. The aqueous layer was concentrated to provide the title compound (0.70 grams, 78%, a 3:1 mixture of exo/endo diastereomers) as a pale yellow solid.

Workup

  1. concentrationThe aqueous layer was concentrated

Sources & evidence

ORD record
ord-4dcbce3c48f84e418a673cee0f8625ed
Source dataset
uspto-grants-2000_08
Patent number
US06110964

Reaction notes

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