HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ammonium Hydroxide → 2-Chloro-4-methylpyridine-3-carboxamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ammonium Hydroxide | HCID 14923 | — |
| Reactant | 2-Chloro-4-methyl-nicotinonitrile | HCID 12387736 | — |
| Solvent | Sulfuric Acid | HCID 1118 | — |
| Product | 2-Chloro-4-methylpyridine-3-carboxamide | HCID 10942886 | 69% |
Reaction Steps
A solution of 6.33 g of 2-chloro-4-methyl-3-pyridine carbonitrile (9) in 6 mL concentrated H2SO4 was stirred at 100° C. for one hour, added ice water, made alkaline with ammonium hydroxide and extracted with ethyl acetate. The extract was dried and the solvent removed to leave a crystalline residue. Recrystallization from ethyl acetate gave 4.9 g (69%) of (10).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06111112 |
| Source dataset | uspto-grants-2000_08 |
| ORD ID | ord-6ff931a77aef49049696122b83f1db21 |
| Source note | uspto-grants-2000_08 |