反应详情

A solution of 6.33 g of 2-chloro-4-methyl-3-pyridine carbonitrile (9) in 6 mL concentrated H2SO4 was stirred at 100° C. for one hour, added ice water, made alkaline with ammonium hydroxide and extracted with ethyl acetate. The extract was dried and the solvent removed to leave a crystalline residue. Recrystallization from ethyl acetate gave 4.9 g (69%) of (10).

1. extractionextracted with ethyl acetate
2. customThe extract was dried
3. customthe solvent removed
4. customto leave a crystalline residue
5. customRecrystallization from ethyl acetate