Water → HCID 57066556, 화합물

HRID 1873095노트

반응식

HRID 1873095 반응식
[CH3:1][C:2]1[CH2:3][C@H:4]([OH:11])[CH2:5][C:6]([CH3:10])([CH3:9])[C:7]=1[CH3:8].[H-].[Na+].Br[CH2:15][C:16]1[CH:25]=[CH:24][C:23]2[C:18](=[CH:19][CH:20]=[CH:21][CH:22]=2)[CH:17]=1.O>COCCOC>[CH:17]1[C:18]2[C:23](=[CH:22][CH:21]=[CH:20][CH:19]=2)[CH:24]=[CH:25][C:16]=1[CH2:15][O:11][C@@H:4]1[CH2:5][C:6]([CH3:10])([CH3:9])[C:7]([CH3:8])=[C:2]([CH3:1])[CH2:3]1

참가 물질

6

반응물 4

HCID 962WaterHCID 24758Sodium hydrideHCID 703202-BromomethylnaphthaleneHCID 57184026HCID 57184026, 화합물

생성물 1

HCID 57066556HCID 57066556, 화합물수율 97%

시약·촉매·용매 1

HCID 80711,2-Dimethoxyethane용매2회

실험 절차

2 g (13 mmol) of (1S)-3,4,5,5-tetramethyl-3-cyclohexen-1-ol prepared in Examples 2A and 2B were dissolved in 10 ml of DME and added dropwise to a suspension of 965 mg (38.9 mmol) of NaH in 10 ml of DME at RT. After evolution of gas had ceased, 14 mmol of 2-bromomethylnaphthalene were added dropwise. Reaction was complete after stirring at RT for 12 h. 50 ml of water were added to the mixture, which was then extracted twice with 50 ml of ether. Chromatography of the residue as in Example 3A resulted in 3.7 g (97%) of the abovementioned product.

후처리

  1. customReaction
  2. extractionwas then extracted twice with 50 ml of ether

출처 및 근거

ORD 기록
ord-386b025cd32a4f56886440906563a873
출처 데이터셋
uspto-grants-2000_08
특허 번호
US06111125

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