反应详情

A biphasic mixture of methanesulfonic acid 4-(6-chloro-benzo[b]naphtho[2,3-d]thiophen-11-yl)-phenyl ester (0.917 g, 2.09 mmol) in dioxane (13 mL) and a solution of sodium hydroxide (2.5 N, 6.7 mL, 16.7 mmol, 8 eq) was heated at reflux overnight. After cooling to room temperature the reaction mixture was combined with water (50 mL), acidified with concentrated hydrochloric acid, and stirred for 15 minutes. The crude white solid product was collected by filtration, redissolved in ether, combined with silica gel, and the solvent was removed. The adsorbate was flash chromatographed (gradient 85/15-80/20 petroleum ether/ethyl acetate) to give the title compound as a white solid (0.705 g, 94%); mp 193-195° C.; NMR (CDCl3); δ 8.37 (ddd, J=8, 1, Hz, 1H), 7.81 (ddd, J=8, 1, 1 Hz, 1H), 7.68-7.63 (m, 2H), 7.44 (ddd, J=8, 7, 1 Hz, 1H), 7.39 (ddd, J=8, 7, 1 Hz, 1H), 7.29-7.26 (m, 2H,), 7.14-7.09 (m, 3H), 6.81 (ddd, J=8, 1, 1 Hz, 1H), 5.01 (d, J=4 Hz, 1H); MS (+EI): [M+], 1 chlorine isotope pattern, 360 (100%), 362 (45%); Anal. calc. for C22H13ClOS: C, 73.23, H, 3.63, N, 0.00. Found: C, 72.86, H, 3.24, N, 0.04.

1. temperatureat reflux overnight
2. filtrationThe crude white solid product was collected by filtration
3. dissolutionredissolved in ether
4. customthe solvent was removed
5. customchromatographed (gradient 85/15-80/20 petroleum ether/ethyl acetate)