Zaltoprofen → HCID 9883399, compound
Reaction equation
[CH3:1][CH:2]([C:19]([OH:21])=[O:20])[C:3]1[CH:4]=[CH:5][C:6]2[S:18][C:17]3[CH:16]=[CH:15][CH:14]=[CH:13][C:12]=3[C:10](=[O:11])[CH2:9][C:7]=2[CH:8]=1.NC1C=CC(C(C)C(O)=[O:31])=CC=1CC(O)=O.C1(S)C=CC=CC=1>>[C:10]([CH2:9][C:7]1[CH:8]=[C:3]([CH:2]([CH3:1])[C:19]([OH:21])=[O:20])[CH:4]=[CH:5][C:6]=1[S:18][C:17]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1)([OH:11])=[O:31]Participants
4
Procedure
Preparation-I of the invention for preparing Zaltoprofen is characterized in that 2-(4-amino-3-carboxymethylphenyl)propionic acid or its salt is diazotized and then reacted with thiophenol to give 2-(3-carboxymethyl-4-phenylthiophenyl)propionic acid or its salt, and the resulting product is then subjected to cyclization reaction. Preparation-I is illustrated in the following reaction scheme I: ##STR7## 1) Preparation of 2-(3-carboxymethyl-4-phenylthiophenyl)propionic acid or its salt
Sources & evidence
- ORD record
- ord-e0ed1c967cbc456b83f5bccb10d0bcd8
- Source dataset
- uspto-grants-2000_08
- Patent number
- US06111115
Reaction notes
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