反应详情

3.65 g (11.0 mmol) of 2-(4-ethoxy-2,3-difluorophenyl)-5-propenylselenophene are hydrogenated in 35 ml of ethyl acetate, in the presence of Pd/C (5% of Pd) at atmospheric pressure and RT. The reaction soln. is filtered and concentrated to dryness, and the crude product is purified by column chromatography (SiO2, n-heptane:EtOAc=4:1→2:1). The further purification is carried out by recrystallisation from n-heptane. 2-(4-Ethoxy-2,3-difluorophenyl)-5-propylselenophene is obtained as a colourless solid (m.p. 64° C.).

1. filtrationis filtered
2. concentrationconcentrated to dryness
3. customthe crude product is purified by column chromatography (SiO2, n-heptane:EtOAc=4:1→2:1)
4. customThe further purification
5. customis carried out by recrystallisation from n-heptane