Dichloromethane → methyl 3-(4-fluorophenyl)-1H-indole-6-carboxylate

HRID 187345Notes

Reaction equation

HRID 187345 reaction equation
[Cl:35][CH2:36][Cl:37].[F:1][c:2]1[cH:3][cH:4][c:5](-[c:8]2[cH:9][n:10]([C:21]([O:22][C:23]([CH3:24])([CH3:25])[CH3:26])=[O:27])[c:11]3[cH:12][c:13]([C:17](=[O:18])[O:19][CH3:20])[cH:14][cH:15][c:16]23)[cH:6][cH:7]1.[OH:28][C:29]([C:30]([F:31])([F:32])[F:33])=[O:34]>>[F:1][c:2]1[cH:3][cH:4][c:5](-[c:8]2[cH:9][nH:10][c:11]3[cH:12][c:13]([C:17](=[O:18])[O:19][CH3:20])[cH:14][cH:15][c:16]23)[cH:6][cH:7]1

Participants

4

Reactant 3

HCID 6344DichloromethaneHCID 6422Trifluoroacetic acidHCID 596257541-tert-Butyl 6-methyl 3-(4-fluorophenyl)-1H-indole-1,6-dicarboxylate

Product 1

HCID 59625721methyl 3-(4-fluorophenyl)-1H-indole-6-carboxylate

Sources & evidence

ORD record
ord-5aef8589f72c4a0b93de0830b738d81b
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (6/10)

Reaction notes

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