反应详情

3-Bromo-4-methylbenzoic acid (10 g), N-bromosuccinimide (8.7 g) and 2,2′-azobisisobutyronitrile (0.4 g) were suspended in carbon tetrachloride (50 ml) and then heated to reflux for 2 hours. The mixture was returned to room temperature and added a 15% aqueous solution of citric acid (20 ml), and stirred for some time. Resulting crystals were filtered and washed with the 15% aqueous solution of citric acid (20 ml), and then dried, to obtain 3-bromo-4-(bromomethyl)benzoic acid (6 g).

1. temperatureheated
2. temperatureto reflux for 2 hours
3. customwas returned to room temperature
4. customResulting crystals
5. filtrationwere filtered
6. washwashed with the 15% aqueous solution of citric acid (20 ml)
7. customdried