Acetic Anhydride → HCID 44183405, compound

HRID 1873482Notes

Reaction equation

HRID 1873482 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([C:9]2([C:26]([F:29])([F:28])[F:27])[CH2:13][C:12]([C:14]3[C:23]4[C:18](=[CH:19][CH:20]=[CH:21][CH:22]=4)[C:17]([CH2:24][NH2:25])=[CH:16][CH:15]=3)=[N:11][CH2:10]2)[CH:5]=[C:6]([Cl:8])[CH:7]=1.[C:30](OC(=O)C)(=[O:32])[CH3:31]>C1COCC1>[Cl:1][C:2]1[CH:3]=[C:4]([C:9]2([C:26]([F:28])([F:29])[F:27])[CH2:13][C:12]([C:14]3[C:23]4[C:18](=[CH:19][CH:20]=[CH:21][CH:22]=4)[C:17]([CH2:24][NH:25][C:30](=[O:32])[CH3:31])=[CH:16][CH:15]=3)=[N:11][CH2:10]2)[CH:5]=[C:6]([Cl:8])[CH:7]=1

Participants

4

Reactant 2

HCID 7918Acetic AnhydrideHCID 58092075HCID 58092075, compound

Product 1

HCID 44183405HCID 44183405, compoundYield 58%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

1-{4-[3-(3,5-dichlorophenyl)-3-(trifluoromethyl)-3,4-dihydro-2H-pyrrol-5-yl]naphthalen-1-yl}methanamine (0.1 g) was dissolved in THF (10 ml), and was added acetic anhydride (0.04 g) thereto. The mixture was stirred for 4 hours at room temperature. The mixture was concentrated under reduced pressure to give residual material which was purified by silica gel chromatography, to obtain the desired compound (63 mg) in a yield of 58%.

Workup

  1. concentrationThe mixture was concentrated under reduced pressure
  2. customto give residual material which
  3. customwas purified by silica gel chromatography

Sources & evidence

ORD record
ord-1b42bae8c7e84abfbbc01e2034d5d1df
Source dataset
uspto-grants-2012_11
Patent number
US08304371B2

Reaction notes

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