Thionyl Chloride → HCID 59160958, compound

HRID 1873579Notes

Reaction equation

HRID 1873579 reaction equation
[N:1]1[CH:6]=[CH:5][C:4]([NH:7][C:8]2[N:13]=[C:12]([CH2:14]O)[CH:11]=[CH:10][CH:9]=2)=[CH:3][CH:2]=1.S(Cl)([Cl:18])=O>ClCCl>[Cl:18][CH2:14][C:12]1[N:13]=[C:8]([NH:7][C:4]2[CH:5]=[CH:6][N:1]=[CH:2][CH:3]=2)[CH:9]=[CH:10][CH:11]=1

Participants

4

Reactant 2

HCID 24386Thionyl ChlorideHCID 59161030HCID 59161030, compound

Product 1

HCID 59160958HCID 59160958, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

50 mg (0.22 mmol) of the compound from Example 35A and 53 mg (0.44 mmol) of thionyl chloride are initially charged at 0° C. in 1.5 ml of dichloromethane and, after warming to RT, stirred at this temperature for 12 h. The solvent is removed on a rotary evaporator and the product that remains is directly reacted further.

Workup

  1. customThe solvent is removed on a rotary evaporator
  2. customthe product that remains is directly reacted further

Sources & evidence

ORD record
ord-4520b1f29fee494f9fc2a54cc33257b5
Source dataset
uspto-grants-2012_11
Patent number
US08304412B2

Reaction notes

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