HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Sulfide → HCID 178433544, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Sulfide | HCID 14804 | — |
| Reactant | 2-Chloro-6-methyl-4-(tetrahydro-2H-pyran-2-yl)pyridine-3,5-dicarbonitrile | HCID 86638396 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 178433544 | HCID 178433544 | — |
Reaction Steps
471 mg (1.35 mmol) of the compound from Example 40A are initially charged in 4 ml of dry DMF, and 126 mg (1.62 mmol) of sodium sulfide are added. The reaction mixture is stirred at RT for 12 h. The solvent is then removed on a rotary evaporator and the residue is purified chromatographically on silica gel 60 (mobile phase: gradient dichloromethane/ethanol 200:1→5:1).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08304412B2 |
| Source dataset | uspto-grants-2012_11 |
| ORD ID | ord-b3dc74507d3440e58c399b5a6527ceae |
| Source note | uspto-grants-2012_11 |