反应详情

471 mg (1.35 mmol) of the compound from Example 40A are initially charged in 4 ml of dry DMF, and 126 mg (1.62 mmol) of sodium sulfide are added. The reaction mixture is stirred at RT for 12 h. The solvent is then removed on a rotary evaporator and the residue is purified chromatographically on silica gel 60 (mobile phase: gradient dichloromethane/ethanol 200:1→5:1).

1. customThe solvent is then removed on a rotary evaporator
2. customthe residue is purified chromatographically on silica gel 60 (mobile phase: gradient dichloromethane/ethanol 200:1→5:1)