HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1873687Generated: November 2, 2026
1,4-Dioxane hydrochloride → 4-(2-Fluoro-4-(3-(2-phenylacetyl)thioureido)phenoxy)-7-methoxyquinoline-6-carboxylic acid hydrochloride
https://huagongshe.com/reaction/1873687
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 1,4-Dioxane hydrochloride | HCID 20443148 | — |
| Reactant | tert-Butyl 4-(2-fluoro-4-(3-(2-phenylacetyl)thioureido)phenoxy)-7-methoxyquinoline-6-carboxylate | HCID 86650700 | — |
| Product | 4-(2-Fluoro-4-(3-(2-phenylacetyl)thioureido)phenoxy)-7-methoxyquinoline-6-carboxylic acid hydrochloride | HCID 86650698 | 79% |
Reaction Steps
Compound 1d (88.0 mg) was dissolved in 4N HCl-dioxane solution, followed by stirring at 70° C. for 1 hour. The precipitate in the reaction mixture was filtrated, to thereby yield compound 1e (67.1 mg, yield: 79%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08304427B2 |
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| Source dataset | uspto-grants-2012_11 |
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| ORD ID | ord-5b2ec7f7397a40f09e5387287803e096 |
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| Source note | uspto-grants-2012_11 |
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