Hydrochloric Acid → HCID 66916241, compound

HRID 1873695Notes

Reaction equation

HRID 1873695 reaction equation
[NH2:1][C:2]1[CH:24]=[CH:23][C:5]([O:6][C:7]2[C:16]3[C:11](=[CH:12][C:13]([O:21][CH3:22])=[C:14]([C:17]([O:19]C)=[O:18])[CH:15]=3)[N:10]=[CH:9][CH:8]=2)=[C:4]([F:25])[CH:3]=1.CO.[OH-].[Na+].Cl>O>[NH2:1][C:2]1[CH:24]=[CH:23][C:5]([O:6][C:7]2[C:16]3[C:11](=[CH:12][C:13]([O:21][CH3:22])=[C:14]([C:17]([OH:19])=[O:18])[CH:15]=3)[N:10]=[CH:9][CH:8]=2)=[C:4]([F:25])[CH:3]=1

Participants

6

Reactant 4

HCID 313Hydrochloric AcidHCID 887MethanolHCID 14798Sodium HydroxideHCID 66916282Methyl 4-(4-amino-2-fluorophenoxy)-7-methoxyquinoline-6-carboxylate

Product 1

HCID 66916241HCID 66916241, compoundYield 90%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

Compound 39b (1.0 g) was added to methanol (10 mL), and 4M aqueous sodium hydroxide (650 μL) and water (400 μL) were further added thereto, followed by stirring at room temperature for 2 hours. After completion of reaction, 6N aqueous hydrochloric acid was added to the reaction mixture, to thereby adjust the pH to 3, and the precipitate was filtrated, whereby compound 39c was yielded (862 mg, yield: 90%).

Workup

  1. additionwere further added
  2. additionwas added to the reaction mixture
  3. filtrationthe precipitate was filtrated

Sources & evidence

ORD record
ord-d7d62e3529aa402381a804b121bcb24f
Source dataset
uspto-grants-2012_11
Patent number
US08304427B2

Reaction notes

Loading…