HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dimethylacetamide → 4-(3-(2-(2-Fluorophenyl)acetylthioureido)-2-fluorophenoxy)-7-methoxyquinoline-6-carboxylic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dimethylacetamide | HCID 31374 | — |
| Reactant | HCID 66916241 | HCID 66916241 | — |
| Reactant | tert-Butyl 4-(2-fluoro-4-(3-(2-phenylacetyl)thioureido)phenoxy)-7-methoxyquinoline-6-carboxylate | HCID 86650700 | — |
| Reactant | 2-Fluorophenylacetyl thioisocyanate | HCID 86650716 | — |
| Solvent | Ethanol | HCID 702 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | 4-(3-(2-(2-Fluorophenyl)acetylthioureido)-2-fluorophenoxy)-7-methoxyquinoline-6-carboxylic acid | HCID 86650715 | — |
Reaction Steps
Similar to the synthesis of compound 1d, from compound 39c (1.79 g), 2-fluorophenylacetyl thioisocyanate (1.97 g), and a solvent mixture of N,N-dimethylacetamide (30 mL), toluene (30 mL), and ethanol (6 mL), carboxylic acid 39d was yielded as a crude product (1.89 g, yield: 89%). The crude product was employed in a subsequent reaction without further purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08304427B2 |
| Source dataset | uspto-grants-2012_11 |
| ORD ID | ord-c0a84ccf8bf245d69278f49993035784 |
| Source note | uspto-grants-2012_11 |