反应详情

Similar to the synthesis of compound 1d, from compound 39c (1.79 g), 2-fluorophenylacetyl thioisocyanate (1.97 g), and a solvent mixture of N,N-dimethylacetamide (30 mL), toluene (30 mL), and ethanol (6 mL), carboxylic acid 39d was yielded as a crude product (1.89 g, yield: 89%). The crude product was employed in a subsequent reaction without further purification.