2-Amino-1-butanol, (+)- → HCID 66916241, compound

HRID 1873697Notes

Reaction equation

HRID 1873697 reaction equation
[F:1][C:2]1[CH:30]=[C:29]([NH:31]C(NC(=O)CC2C=CC=CC=2)=S)[CH:28]=[CH:27][C:3]=1[O:4][C:5]1[C:14]2[C:9](=[CH:10][C:11]([O:25][CH3:26])=[C:12]([C:15](NCCCOC(C)C)=[O:16])[CH:13]=2)[N:8]=[CH:7][CH:6]=1.N[C@@H](CC)C[OH:47].NC1C=CC(OC2C3C(=CC(OC)=C(C(N[C@@H](CC)CO)=O)C=3)N=CC=2)=C(F)C=1>>[NH2:31][C:29]1[CH:28]=[CH:27][C:3]([O:4][C:5]2[C:14]3[C:9](=[CH:10][C:11]([O:25][CH3:26])=[C:12]([C:15]([OH:47])=[O:16])[CH:13]=3)[N:8]=[CH:7][CH:6]=2)=[C:2]([F:1])[CH:30]=1

Participants

4

Reactant 3

HCID 1200842-Amino-1-butanol, (+)-HCID 66916390(S)-4-(4-Amino-2-fluorophenoxy)-N-(1-hydroxybutan-2-yl)-7-methoxyquinoline-6-carboxamideHCID 86650701HCID 86650701, compound

Product 1

HCID 66916241HCID 66916241, compoundYield 81%

Procedure

Similar to the synthesis of compound 1, from compound 39c (300 mg), DMTMM•n-hydrate (329 mg), and (S)-2-aminobutan-1-ol (113 μL), compound 41a was yielded (297 mg, yield: 81%).

Sources & evidence

ORD record
ord-562fc70197df478495640a762edca334
Source dataset
uspto-grants-2012_11
Patent number
US08304427B2

Reaction notes

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