4-(4-amino-2-fluorophenoxy)-N-(2-hydroxy-2-methylpropyl)-7-methoxyquinoline-6-carboxamide → 2-Propanol, 1-amino-2-methyl-

HRID 1873698Notes

Reaction equation

HRID 1873698 reaction equation
[F:1][C:2]1[CH:30]=[C:29]([NH:31]C(NC(=O)CC2C=CC=CC=2)=S)[CH:28]=[CH:27][C:3]=1[O:4][C:5]1[C:14]2[C:9](=[CH:10][C:11]([O:25][CH3:26])=[C:12]([C:15](NCCCOC(C)C)=[O:16])[CH:13]=2)[N:8]=[CH:7][CH:6]=1.NC1C=CC([O:49]C2C3C(=CC(OC)=C(C([NH:62][CH2:63][C:64]([OH:67])([CH3:66])[CH3:65])=O)C=3)N=CC=2)=C(F)C=1>>[NH2:31][C:29]1[CH:28]=[CH:27][C:3]([O:4][C:5]2[C:14]3[C:9](=[CH:10][C:11]([O:25][CH3:26])=[C:12]([C:15]([OH:49])=[O:16])[CH:13]=3)[N:8]=[CH:7][CH:6]=2)=[C:2]([F:1])[CH:30]=1.[NH2:62][CH2:63][C:64]([CH3:66])([OH:67])[CH3:65]

Participants

4

Reactant 2

HCID 669164354-(4-amino-2-fluorophenoxy)-N-(2-hydroxy-2-methylpropyl)-7-methoxyquinoline-6-carboxamideHCID 86650701HCID 86650701, compound

Product 2

HCID 951022-Propanol, 1-amino-2-methyl-HCID 66916241HCID 66916241, compound

Procedure

Similar to the synthesis of compound 1, from compound 39c (103 mg), DMTMM•n-hydrate (104 mg), and 1-amino-2-methylpropan-2-ol (42 mg), compound 42a was yielded (66.3 mg, yield: 53%).

Sources & evidence

ORD record
ord-37b8e3503e964a8c8cc963d45223ed3d
Source dataset
uspto-grants-2012_11
Patent number
US08304427B2

Reaction notes

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