HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-(4-amino-2-fluorophenoxy)-N-(2-hydroxy-2-methylpropyl)-7-methoxyquinoline-6-carboxamide → 2-Propanol, 1-amino-2-methyl-
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-(4-amino-2-fluorophenoxy)-N-(2-hydroxy-2-methylpropyl)-7-methoxyquinoline-6-carboxamide | HCID 66916435 | — |
| Reactant | HCID 86650701 | HCID 86650701 | — |
| Product | 2-Propanol, 1-amino-2-methyl- | HCID 95102 | — |
| Product | HCID 66916241 | HCID 66916241 | — |
Reaction Steps
Similar to the synthesis of compound 1, from compound 39c (103 mg), DMTMM•n-hydrate (104 mg), and 1-amino-2-methylpropan-2-ol (42 mg), compound 42a was yielded (66.3 mg, yield: 53%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08304427B2 |
| Source dataset | uspto-grants-2012_11 |
| ORD ID | ord-37b8e3503e964a8c8cc963d45223ed3d |
| Source note | uspto-grants-2012_11 |