tert-Butyl (triphenylphosphoranylidene) acetate → 3-[4-(4-Fluoro-phenyl)-thiazol-2-yl]-acrylic Acid Tert-butyl Ester

HRID 1873764Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1873764
[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[N:9]=[C:10]([CH:13]=O)[S:11][CH:12]=2)=[CH:4][CH:3]=1.[C:15]([O:19][C:20]([CH:22]=P(C1C=CC=CC=1)(C1C=CC=CC=1)C1C=CC=CC=1)=[O:21])([CH3:18])([CH3:17])[CH3:16]>C1COCC1>[C:15]([O:19][C:20](=[O:21])[CH:22]=[CH:13][C:10]1[S:11][CH:12]=[C:8]([C:5]2[CH:4]=[CH:3][C:2]([F:1])=[CH:7][CH:6]=2)[N:9]=1)([CH3:18])([CH3:17])[CH3:16]

Komponenten

4

Edukt 2

HCID 256127tert-Butyl (triphenylphosphoranylidene) acetateHCID 37040054-(4-Fluorophenyl)-1,3-thiazole-2-carbaldehyde

Produkt 1

HCID 687147063-[4-(4-Fluoro-phenyl)-thiazol-2-yl]-acrylic Acid Tert-butyl Ester

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8028TetrahydrofuranLösungsmittel

Versuchsvorschrift

2 g (10.57 mmol) of 4-(4-fluoro-phenyl)-thiazole-2-carbaldehyde and 4.177 g (11.09 mmol) of (tert-butoxycarbonylmethylene)triphenylphosphorane in 25 ml of THF were stirred at room temperature for 2 h. The reaction mixture was evaporated, and the residue was used in the subsequent step without purification.

Aufarbeitung

  1. customThe reaction mixture was evaporated
  2. customthe residue was used in the subsequent step without purification

Quellen und Nachweise

ORD-Eintrag
ord-90fbf2ca08cf41b8a1809dce23d16d66
Quelldatensatz
uspto-grants-2012_11
Patentnummer
US08304438B2

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