HuagongsheHuagongshe Chemistry Print Report · For research reference only
tert-Butyl (triphenylphosphoranylidene) acetate → 3-[4-(4-Fluoro-phenyl)-thiazol-2-yl]-acrylic Acid Tert-butyl Ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | tert-Butyl (triphenylphosphoranylidene) acetate | HCID 256127 | — |
| Reactant | 4-(4-Fluorophenyl)-1,3-thiazole-2-carbaldehyde | HCID 3704005 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 3-[4-(4-Fluoro-phenyl)-thiazol-2-yl]-acrylic Acid Tert-butyl Ester | HCID 68714706 | — |
Reaction Steps
2 g (10.57 mmol) of 4-(4-fluoro-phenyl)-thiazole-2-carbaldehyde and 4.177 g (11.09 mmol) of (tert-butoxycarbonylmethylene)triphenylphosphorane in 25 ml of THF were stirred at room temperature for 2 h. The reaction mixture was evaporated, and the residue was used in the subsequent step without purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08304438B2 |
| Source dataset | uspto-grants-2012_11 |
| ORD ID | ord-90fbf2ca08cf41b8a1809dce23d16d66 |
| Source note | uspto-grants-2012_11 |