HuagongsheHuagongshe Chemistry Print Report · For research reference only
Diisopropylamine → 3-[4-(4-Fluoro-phenyl)-thiazol-2-yl]-N,N-diisopropyl-acrylamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Diisopropylamine | HCID 7912 | — |
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | Methanaminium, N-((dimethylamino)(3H-1,2,3-triazolo(4,5-b)pyridin-3-yloxy)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1) | HCID 9886157 | — |
| Reactant | 3-[4-(4-Fluoro-phenyl)-thiazol-2-yl]-acrylic Acid | HCID 68713482 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 3-[4-(4-Fluoro-phenyl)-thiazol-2-yl]-N,N-diisopropyl-acrylamide | HCID 68710600 | — |
Reaction Steps
98 mg (0.39 mmol) of 3-[4-(4-fluoro-phenyl)-thiazol-2-yl]-acrylic acid, 79.6 mg (0.78 mmol) of diisopropylamine, 119.35 mg (1.17 mmol) of triethylamine and 164.5 mg (0.43 mmol) of HATU in 5 ml of DMF were stirred at room temperature for 2 h. The reaction mixture was concentrated, and water and ethyl acetate were added. The organic phase was separated, washed and evaporated. The residue was purified by chromatography (RP18). Yield: 39 mg.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08304438B2 |
| Source dataset | uspto-grants-2012_11 |
| ORD ID | ord-8da3d2a4f8374f5cad5dfc9b6a610118 |
| Source note | uspto-grants-2012_11 |